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Nickel-catalyzed direct cross-coupling of heterocyclic phosphonium salts with aryl bromides
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2021-10-26 , DOI: 10.1039/d1qo01474a
Yan-Ying Cui 1 , Wen-Xin Li 1 , Na-Na Ma 1 , Chuanji Shen 2 , Xiaocong Zhou 2 , Xue-Qiang Chu 1 , Weidong Rao 3 , Zhi-Liang Shen 1
Affiliation  

The direct cross-coupling of heterocyclic phosphonium salts with aryl bromides was successfully realized by performing the reactions in THF at ambient temperature with the aid of a nickel(II) catalyst, the 1,10-phenanthroline-5,6-dione ligand, magnesium turnings, and lithium chloride, providing an easy access to 4-arylated pyridine, quinoline, quinoxaline, and pyrazine.

中文翻译:

镍催化的杂环鏻盐与芳基溴化物的直接交叉偶联

在镍( II )催化剂、1,10-菲咯啉-5,6-二酮配体、镁的帮助下,在室温下在THF中进行反应,成功地实现了杂环鏻盐与芳基溴化物的直接交叉偶联。车屑和氯化锂,可轻松获取 4-芳基吡啶、喹啉、喹喔啉和吡嗪。
更新日期:2021-11-03
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