Issue 24, 2021
From the journal:

Organic Chemistry Frontiers

Nickel-catalyzed direct cross-coupling of heterocyclic phosphonium salts with aryl bromides†

Yan-Ying Cui,a   Wen-Xin Li,a   Na-Na Ma,a   Chuanji Shen,b   Xiaocong Zhou,*b   Xue-Qiang Chu, ORCID logo a   Weidong Rao ORCID logo c  and  Zhi-Liang Shen ORCID logo *a  

* Corresponding authors

a Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
E-mail: ias_zlshen@njtech.edu.cn

b College of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China
E-mail: xczhou@zjxu.edu.cn

c Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Abstract

The direct cross-coupling of heterocyclic phosphonium salts with aryl bromides was successfully realized by performing the reactions in THF at ambient temperature with the aid of a nickel(II) catalyst, the 1,10-phenanthroline-5,6-dione ligand, magnesium turnings, and lithium chloride, providing an easy access to 4-arylated pyridine, quinoline, quinoxaline, and pyrazine.

Graphical abstract: Nickel-catalyzed direct cross-coupling of heterocyclic phosphonium salts with aryl bromides

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Article information

DOI
https://doi.org/10.1039/D1QO01474A
Article type
Research Article
Submitted
30 Sep 2021
Accepted
25 Oct 2021
First published
26 Oct 2021

Org. Chem. Front., 2021,8, 6931-6936

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Nickel-catalyzed direct cross-coupling of heterocyclic phosphonium salts with aryl bromides

Y. Cui, W. Li, N. Ma, C. Shen, X. Zhou, X. Chu, W. Rao and Z. Shen, Org. Chem. Front., 2021, 8, 6931 DOI: 10.1039/D1QO01474A

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