Purpose

To evaluate the performance of precorneal and prelens non-invasive tear break-up time (NIBUT) measurements to determine tear instability in contact lens (CL) wearers.

Methods

In this study, 50 eyes of 25 CL wearers were evaluated. Precorneal first and average NIBUTs and fluorescein tear break-up time (FBUT) were measured before wearing CLs in the morning. Those with FBUT less than 10 s were considered to have tear instability. After wearing CL, first and average prelens NIBUTs were measured at the 30th minute. The receiver operating characteristic (ROC) curve was analyzed to evaluate the performance of NIBUT measurements in the diagnosis of tear instability.

Results

The FBUT value had a significant correlation with first and average precorneal NIBUT values (p < 0.001, r = 0.653 and p < 0.001, r = 0.628, respectively). The FBUT value had no correlation with the prelens first and average NIBUT values (p = 0.542 and p = 0.263, respectively). To understand the relationship between the precorneal and prelens NIBUT values measured by the automated method, their correlation was evaluated. There was no significant correlation between the precorneal and prelens NIBUTs (for all; p > 0.05). The area under curve (AUC) in ROC curve for the first and average precorneal NIBUTs were 0.842 (p < 0.001) and 0.810 (p < 0.001), respectively. The AUC values for the first and average prelens NIBUTs at the 30th minute of CL wear were 0.586 and 0.619, respectively (p = 0.317 and p = 0.166, respectively).

Conclusions

Precorneal NIBUT measurements may be useful in diagnosing tear instability. Prelens NIBUT values are not yet capable of adequately defining the tear film dynamics in CL wearers.

中文翻译：

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非侵入性泪液破裂时间确定隐形眼镜佩戴者泪液不稳定性的能力

目的

评估角膜前和镜片前非侵入性泪液破裂时间 (NIBUT) 测量的性能，以确定隐形眼镜 (CL) 佩戴者的泪液不稳定性。

方法

在这项研究中，对 25 名 CL 佩戴者的 50 只眼睛进行了评估。在早上佩戴 CL 之前测量角膜前首次和平均 NIBUT 和荧光素泪液破裂时间 (FBUT)。FBUT 小于 10 s 的人被认为具有撕裂不稳定性。佩戴 CL 后，在第 30 分钟测量第一次和平均预透镜 NIBUT。分析受试者工作特征 (ROC) 曲线以评估 NIBUT 测量在诊断泪液不稳定性中的性能。

结果

FBUT 值与第一和平均角膜前 NIBUT 值具有显着相关性（分别为p  < 0.001，r  = 0.653 和p  < 0.001，r  = 0.628）。FBUT 值与 prelens 第一和平均 NIBUT 值没有相关性（分别为p  = 0.542 和p  = 0.263）。为了了解通过自动化方法测量的角膜前和镜片前 NIBUT 值之间的关系，评估了它们的相关性。角膜前 NIBUT 和晶状体前 NIBUT 之间没有显着相关性（对所有人而言；p  > 0.05）。第一次和平均角膜前 NIBUT 的 ROC 曲线下面积 (AUC) 为 0.842 ( p < 0.001) 和 0.810 ( p  < 0.001)。在 CL 磨损的第 30 分钟，第一次和平均预透镜 NIBUT 的 AUC 值分别为 0.586 和 0.619（分别为p  = 0.317 和p  = 0.166）。

结论

角膜前 NIBUT 测量可能有助于诊断泪液不稳定性。Prelens NIBUT 值尚不能充分定义 CL 佩戴者的泪膜动力学。