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Ability of non-invasive tear break-up time to determine tear instability in contact lens wearers

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Abstract

Purpose

To evaluate the performance of precorneal and prelens non-invasive tear break-up time (NIBUT) measurements to determine tear instability in contact lens (CL) wearers.

Methods

In this study, 50 eyes of 25 CL wearers were evaluated. Precorneal first and average NIBUTs and fluorescein tear break-up time (FBUT) were measured before wearing CLs in the morning. Those with FBUT less than 10 s were considered to have tear instability. After wearing CL, first and average prelens NIBUTs were measured at the 30th minute. The receiver operating characteristic (ROC) curve was analyzed to evaluate the performance of NIBUT measurements in the diagnosis of tear instability.

Results

The FBUT value had a significant correlation with first and average precorneal NIBUT values (p < 0.001, r = 0.653 and p < 0.001, r = 0.628, respectively). The FBUT value had no correlation with the prelens first and average NIBUT values (p = 0.542 and p = 0.263, respectively). To understand the relationship between the precorneal and prelens NIBUT values measured by the automated method, their correlation was evaluated. There was no significant correlation between the precorneal and prelens NIBUTs (for all; p > 0.05). The area under curve (AUC) in ROC curve for the first and average precorneal NIBUTs were 0.842 (p < 0.001) and 0.810 (p < 0.001), respectively. The AUC values for the first and average prelens NIBUTs at the 30th minute of CL wear were 0.586 and 0.619, respectively (p = 0.317 and p = 0.166, respectively).

Conclusions

Precorneal NIBUT measurements may be useful in diagnosing tear instability. Prelens NIBUT values are not yet capable of adequately defining the tear film dynamics in CL wearers.

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Data availability

All authors declared that all data and materials as well as software application or custom code support their published claims and comply with field standards.

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Funding

The authors declared that this study has received no financial support.

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Authors and Affiliations

  1. Ophthalmology Department, Faculty of Medicine, Kafkas University, 36100, Merkez, Kars, Turkey

    Ersin Muhafiz

  2. Ophthalmology Department, Van Training and Research Hospital, Van, Turkey

    Mehmet Siraç Demir

Authors
  1. Ersin Muhafiz
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  2. Mehmet Siraç Demir
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [EM, MSD], [EM, MSD], and [EM, MSD]. The first draft of the manuscript was written by [EM] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ersin Muhafiz.

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The authors declare that they have no conflict of interest.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Muhafiz, E., Demir, M.S. Ability of non-invasive tear break-up time to determine tear instability in contact lens wearers. Int Ophthalmol 42, 959–968 (2022). https://doi.org/10.1007/s10792-021-02079-3

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  • DOI: https://doi.org/10.1007/s10792-021-02079-3

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