Cardiac patches can help to restore the electrophysiological properties of the heart after myocardial infarction. However, scaffolds for the repair of heart muscle typically require surgical implantation or, if they are injectable, they are not electrically conductive or do not maintain their shape or function. Here, we report the performance, as demonstrated for the repair of infarcted heart muscle in rats and minipigs, of injectable and conductive scaffolds consisting of methacrylated elastin and gelatin, and carbon nanotubes that display shape-memory behaviour, a hierarchical porous structure and a negligible Poisson’s ratio. In rats, the implantation of cell-free patches or patches seeded with rat cardiomyocytes onto the myocardium after ligation of the left anterior descending coronary artery led to functional repair after 4 weeks, as indicated by increases in fractional shortening and the ejection fraction, and by a decrease in the infarcted area. We also observed measures of functional recovery in minipigs with infarcted hearts after the delivery of cell-free patches or patches incorporating cardiomyocytes differentiated from human pluripotent stem cells.

心脏贴片可以帮助恢复心肌梗死后心脏的电生理特性。然而，用于修复心肌的支架通常需要手术植入，或者，如果它们是可注射的，它们不导电或不能保持其形状或功能。在这里，我们报告了由甲基丙烯酸酯弹性蛋白和明胶组成的可注射和导电支架以及显示形状记忆行为、分层多孔结构和可忽略不计的碳纳米管的可注射和导电支架的性能，如修复大鼠和小型猪的梗塞心肌所证明的那样。泊松比。在大鼠中，左冠状动脉前降支结扎后，将无细胞贴片或接种大鼠心肌细胞的贴片植入心肌，4周后功能修复，正如缩短分数和射血分数的增加以及梗塞面积的减少所表明的那样。我们还观察了在提供无细胞贴片或含有从人多能干细胞分化的心肌细胞的贴片后，梗塞心脏小型猪的功能恢复情况。