Oral cancer is the 11th most common cancer in the world with a high morbidity rate. Various conventional therapies have been used for the treatment of oral cancer such as surgery, radiotherapy, and chemotherapy used either alone or in combination but these have many limitations, making them unsuitable for treating oral cancer. Nanotechnology has been emerged out as an innovative tool in the field of oral cancer which has proved to provide effective results overcoming the limitations of conventional drug therapies. This system involves a nanoparticle drug delivery system based on a targeted therapy in which therapeutic drugs or agents act on the targeted cells without affecting normal healthy cells. Literature has shown that several nanoparticles, organic and inorganic nanoparticles, have been used as the drug delivery system in different types of oral cancers such as oral squamous cell carcinoma, cancer of the tongue, head, and neck cancers. Drugs like cisplatin, 5-fluorouracil, methotrexate, doxorubicin, etc., when coated with nano-polymers have shown better results compared with conventional drugs in oral cancer. Other nanoparticles such as liposomes, hydrogels, nanodiamonds, carbon rods, etc. have also been used with minimal side effects. This paper aims to review and discuss various nanotechnology systems in the field of oral cancer and to evaluate the efficacy of these systems in treating oral cancer compared with conventional drug delivery methods.

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了解纳米技术治疗口腔癌：综合评论。

口腔癌是世界上第 11 位最常见的癌症，发病率很高。各种常规疗法已用于治疗口腔癌，例如单独或联合使用的手术、放疗和化疗，但这些疗法具有许多局限性，使其不适用于治疗口腔癌。纳米技术已成为口腔癌领域的一种创新工具，已被证明可以提供克服传统药物治疗局限性的有效结果。该系统涉及基于靶向治疗的纳米颗粒药物递送系统，其中治疗药物或药剂作用于靶细胞而不影响正常健康细胞。文献表明，几种纳米粒子，有机和无机纳米粒子，已被用作不同类型口腔癌的药物递送系统，例如口腔鳞状细胞癌、舌癌、头颈癌。与传统药物相比，顺铂、5-氟尿嘧啶、甲氨蝶呤、多柔比星等药物包覆纳米聚合物后显示出更好的效果。其他纳米粒子，如脂质体、水凝胶、纳米金刚石、碳棒等，也已被使用，副作用最小。本文旨在回顾和讨论口腔癌领域的各种纳米技术系统，并评估这些系统与传统给药方法相比治疗口腔癌的疗效。与传统药物相比，纳米聚合物涂层在口腔癌中显示出更好的效果。其他纳米粒子，如脂质体、水凝胶、纳米金刚石、碳棒等，也已被使用，副作用最小。本文旨在回顾和讨论口腔癌领域的各种纳米技术系统，并评估这些系统与传统给药方法相比治疗口腔癌的疗效。与传统药物相比，纳米聚合物涂层在口腔癌中显示出更好的效果。其他纳米粒子，如脂质体、水凝胶、纳米金刚石、碳棒等，也已被使用，副作用最小。本文旨在回顾和讨论口腔癌领域的各种纳米技术系统，并评估这些系统与传统给药方法相比治疗口腔癌的疗效。