Inflammatory bowel disease (IBD), which significantly affects human health, has two primary presentations: Crohn’s disease and ulcerative colitis (UC). Highland barley is the most common food crop for Tibetans and contains much more β-glucan than any other crop. Highland barley β-glucan (HBBG) can relieve the gastrointestinal dysfunction and promote intestines health. This study aimed to evaluate whether HBBG can relieve UC in mice. A mouse model of UC was established by adding 2% dextran sulfate sodium (DSS) to drinking water for 1 week. UC was alleviated after the introduction of the HBBG diet, as indicated by reductions in the disease activity index (DAI) score, histopathological damage, and the concentration of colonic myeloperoxidase (MPO), along with an improvement in colonic atrophy. Furthermore, we found that HBBG can increase the relative transcriptional levels of genes encoding ZO-1, claudin-1, occludin, and mucin2 (MUC2), thereby reducing intestinal permeability. Additionally, HBBG maintained the balance of proinflammatory and anti-inflammatory cytokines and modulated the structure of the intestinal flora.

中文翻译：

---

青稞提取的 β-葡聚糖可减轻硫酸葡聚糖钠诱导的 C57BL/6J 小鼠溃疡性结肠炎


炎症性肠病（IBD）严重影响人类健康，有两种主要表现：克罗恩病和溃疡性结肠炎（UC）。青稞是藏族最常见的粮食作物，其β-葡聚糖含量远高于其他农作物。青稞β-葡聚糖（HBBG）可以缓解胃肠功能紊乱，促进肠道健康。本研究旨在评估 HBBG 是否可以缓解小鼠的 UC。通过在饮用水中添加2%葡聚糖硫酸钠（DSS）1周建立UC小鼠模型。引入 HBBG 饮食后，UC 得到缓解，表现为疾病活动指数 (DAI) 评分、组织病理学损伤和结肠髓过氧化物酶 (MPO) 浓度的降低，以及结肠萎缩的改善。此外，我们发现 HBBG 可以增加编码 ZO-1、claudin-1、occludin 和 mucin2 (MUC2) 的基因的相对转录水平，从而降低肠道通透性。此外，HBBG 维持促炎和抗炎细胞因子的平衡，并调节肠道菌群的结构。