Protein dynamics implications of the low- and high-temperature denaturation of myoglobin,Physical Review E

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Protein dynamics implications of the low- and high-temperature denaturation of myoglobin
Physical Review E ( IF 2.2 ) Pub Date : 2021-09-24 , DOI: 10.1103/physreve.104.034414
Ramzi R Khuri ₁ , Trung V Phan ₂ , Robert H Austin ₂

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We reinvestigate a simple model used in the literature concerning the thermodynamic analysis of protein cold denaturation. We derive an exact thermodynamic expression for cold denaturation and give a better approximation than exists in the literature for predicting cold denaturation temperatures in the two-state model. We discuss the “dark-side” implications of this work for previous temperature-dependent protein dynamics experiments and discuss microfluidic experimental technologies, which could explore the thermal stability range of proteins below the bulk freezing point of water.

中文翻译：

肌红蛋白低温和高温变性对蛋白质动力学的影响

我们重新研究了文献中使用的关于蛋白质冷变性热力学分析的简单模型。我们推导出了冷变性的精确热力学表达式，并给出了比文献中现有的更好的近似值，用于预测双态模型中的冷变性温度。我们讨论了这项工作对以前的温度依赖性蛋白质动力学实验的“暗面”影响，并讨论了微流体实验技术，这些技术可以探索蛋白质在水的整体冰点以下的热稳定性范围。

更新日期：2021-09-24

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