We aimed to assess whether dynamic arterial spin labeling (dASL), a novel quantitative MRI technique with minimal contamination of subject motion and physiological noises, could detect the longitudinal effect of focused attention meditation (FAM) on resting-state functional connectivity (rsFC). A total of 10 novice meditators who recorded their FAM practice time were scanned at baseline and at the 2-month follow-up. Two-month meditation practice caused significantly increased rsFC between the left medial temporal (LMT) seed and precuneus area and between the right frontal eye (RFE) seed and medial prefrontal cortex. Meditation practice time was found to be positively associated with longitudinal changes of rsFC between the default mode network (DMN) and dorsal attention network (DAN), between DMN and insula, and between DAN and the frontoparietal control network (FPN) but negatively associated with changes of rsFC between DMN and FPN, and between DAN and visual regions. These findings demonstrate the capability of dASL in identifying the FAM-induced rsFC changes and suggest that the practice of FAM can strengthen the efficient control of FPN on fast switching between DMN and DAN and enhance the utilization of attentional resources with reduced focus on visual processing.

中文翻译：

---

使用动态动脉自旋标记冥想对静息状态功能连接的纵向影响：可行性研究

我们旨在评估动态动脉自旋标记 (dASL)，一种新型定量 MRI 技术，对受试者运动和生理噪声的污染最小，是否可以检测集中注意力冥想 (FAM) 对静息状态功能连接 (rsFC) 的纵向影响。在基线和 2 个月的随访中，总共对 10 名记录 FAM 练习时间的新手冥想者进行了扫描。两个月的冥想练习导致左内侧颞 (LMT) 种子和楔前叶区域之间以及右额眼 (RFE) 种子和内侧前额叶皮层之间的 rsFC 显着增加。发现冥想练习时间与默认模式网络 (DMN) 和背侧注意网络 (DAN) 之间、DMN 和脑岛之间的 rsFC 纵向变化呈正相关，DAN 和额顶控制网络 (FPN) 之间，但与 DMN 和 FPN 之间以及 DAN 和视觉区域之间的 rsFC 变化呈负相关。这些发现证明了 dASL 在识别 FAM 诱导的 rsFC 变化方面的能力，并表明 FAM 的实践可以加强 FPN 对 DMN 和 DAN 之间快速切换的有效控制，并提高注意力资源的利用率，减少对视觉处理的关注。