CO2-tuned highly selective reduction of formamides to the corresponding methylamines,Green Chemistry

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CO2-tuned highly selective reduction of formamides to the corresponding methylamines
Green Chemistry ( IF 9.3 ) Pub Date : 2021-09-03 , DOI: 10.1039/d1gc02815d
Zhiqiang Guo ₁ , Tengfei Pang ₂ , Leilei Yan ₂ , Xuehong Wei ₁ , Jianbin Chao ₁ , Chanjuan Xi ₃

Affiliation

We herein describe an efficient, CO₂-tuned and highly selective C–O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH₄ as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO₂ has been investigated in detail, and the mechanism is proposed on the basis of experiments.

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