CO2-tuned highly selective reduction of formamides to the corresponding methylamines

Zhiqiang Guo; Tengfei Pang; Leilei Yan; Xuehong Wei; Jianbin Chao; Chanjuan Xi

doi:10.1039/D1GC02815D

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CO₂-tuned highly selective reduction of formamides to the corresponding methylamines†

Zhiqiang Guo,

*^a Tengfei Pang,^b Leilei Yan,^b Xuehong Wei,*^a Jianbin Chao

^a and Chanjuan Xi

*^c

Author affiliations

* Corresponding authors

^a Scientific Instrument Center, Shanxi University, Taiyuan, P.R. China
E-mail: gzq@sxu.edu.cn, xhwei@sxu.edu.cn

^b School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P.R. China

^c MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: cjxi@tsinghua.edu.cn

Abstract

We herein describe an efficient, CO₂-tuned and highly selective C–O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH₄ as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO₂ has been investigated in detail, and the mechanism is proposed on the basis of experiments.

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Article information

DOI: https://doi.org/10.1039/D1GC02815D
Article type: Communication
Submitted: 06 Aug 2021
Accepted: 03 Sep 2021
First published: 03 Sep 2021

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Green Chem., 2021,23, 7534-7538

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CO₂-tuned highly selective reduction of formamides to the corresponding methylamines

Z. Guo, T. Pang, L. Yan, X. Wei, J. Chao and C. Xi, Green Chem., 2021, 23, 7534 DOI: 10.1039/D1GC02815D

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