An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir,RSC Advances

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An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
RSC Advances ( IF 3.9 ) Pub Date : 2021-09-22 , DOI: 10.1039/d1ra06589k
Ramkumar Moorthy ₁ , Samantha A Kennelly ₁ , Deborah J Rodriguez ₁ , Daniel A Harki ₁

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Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.

中文翻译：

含有 GS-441524 的 RNA 的高效合成：瑞德西韦的核苷前体

瑞德西韦是一种抗病毒核苷氨基磷酸酯，具有对抗多种病毒（包括 SARS-CoV-2）的活性。为了能够使用含有瑞德西韦的RNA来研究病毒聚合酶，我们报告了瑞德西韦的核苷前体GS-441524的亚磷酰胺的有效合成，并使用自动固相RNA合成将其掺入RNA中。

更新日期：2021-09-22

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