Issue 50, 2021
From the journal:

RSC Advances

An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir†

Ramkumar Moorthy,a   Samantha A. Kennelly, ORCID logo a   Deborah J. Rodrigueza  and  Daniel A. Harki ORCID logo *a  

* Corresponding authors

a Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, USA
E-mail: daharki@umn.edu

Abstract

Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.

Graphical abstract: An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir

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Article information

DOI
https://doi.org/10.1039/D1RA06589K
Article type
Paper
Submitted
01 Sep 2021
Accepted
14 Sep 2021
First published
22 Sep 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 31373-31376

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An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir

R. Moorthy, S. A. Kennelly, D. J. Rodriguez and D. A. Harki, RSC Adv., 2021, 11, 31373 DOI: 10.1039/D1RA06589K

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