Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides,Soft Matter

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Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides
Soft Matter ( IF 2.9 ) Pub Date : 2021-09-10 , DOI: 10.1039/d1sm01221e
Meihui Yi ₁ , Jiaqi Guo ₁ , Hongjian He ₁ , Weiyi Tan ₁ , Nya Harmon ₂ , Kesete Ghebreyessus ₂ , Bing Xu ₁

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Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (_pTyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (_pNP) and phosphobiphenyl (_pBP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.

中文翻译：

磷酸双芳香族基序可实现短肽的快速酶促自组装和水凝胶化

酶指导自组装 (EISA) 和水凝胶化是生成软材料的通用方法。碱性磷酸酶催化 EISA 的大多数底物利用磷酸酪氨酸 ( _p Tyr) 作为 EISA 和水凝胶化的酶触发物。_{在这里，我们展示了磷酸萘基 ( p} NP) 和磷酸联苯 ( _p BP) 基序在 EISA 和水凝胶化中作为比磷酸酪氨酸更快的酶触发剂的第一个例子。这项工作说明了快速酶促自组装和水凝胶化的新型酶触发器。

更新日期：2021-09-21

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