Issue 38, 2021

Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides

Abstract

Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (pTyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (pNP) and phosphobiphenyl (pBP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.

Graphical abstract: Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides

Supplementary files

Article information

Article type
Communication
Submitted
20 Aug 2021
Accepted
06 Sep 2021
First published
10 Sep 2021

Soft Matter, 2021,17, 8590-8594

Author version available

Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides

M. Yi, J. Guo, H. He, W. Tan, N. Harmon, K. Ghebreyessus and B. Xu, Soft Matter, 2021, 17, 8590 DOI: 10.1039/D1SM01221E

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