Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers,Biomaterials Science

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Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-09-09 , DOI: 10.1039/d1bm01226f
Qingqing Fan ₁ , Yuan Gao ₁ , Federico Mazur ₁ , Rona Chandrawati ₁

Affiliation

Neurodegenerative disorders (NDDs) are progressive, incurable health conditions that primarily affect brain cells, and result in loss of brain mass and impaired function. Current sensing technologies for NDD detection are limited by high cost, long sample preparation, and/or require skilled personnel. To overcome these limitations, optical sensors, specifically colorimetric sensors, have garnered increasing attention towards the development of a cost-effective, simple, and rapid alternative approach. In this review, we evaluate colorimetric sensing strategies of NDD biomarkers (e.g. proteins, neurotransmitters, bio-thiols, and sulfide), address the limitations and challenges of optical sensor technologies, and provide our outlook on the future of this field.

中文翻译：

基于纳米颗粒的比色传感器检测神经退行性疾病生物标志物

神经退行性疾病 (NDD) 是进行性的、无法治愈的健康状况，主要影响脑细胞，并导致大脑质量损失和功能受损。当前用于 NDD 检测的传感技术受到成本高、样品制备时间长和/或需要熟练人员的限制。为了克服这些限制，光学传感器，特别是比色传感器，越来越关注开发具有成本效益、简单和快速的替代方法。在这篇综述中，我们评估了 NDD 生物标志物（例如蛋白质、神经递质、生物硫醇和硫化物）的比色传感策略，解决了光学传感器技术的局限性和挑战，并提供了对该领域未来的展望。

更新日期：2021-09-16

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