The nucleotide oligomerization domain (NOD)-like receptor 2 (NOD2) is an intracellular pattern recognition receptor that detects components of peptidoglycans from bacterial cell walls. NOD2 regulates bowel microorganisms, provides resistance against infections such as diarrhea, and reduces the risk of inflammatory bowel diseases in humans and mice. We previously demonstrated that a specific porcine NOD2 polymorphism (NOD2-2197A > C) augments the recognition of peptidoglycan components. In this study, the relationships between porcine NOD2-2197A/C genotypes affecting molecular functions and symptoms in a porcine circovirus 2b (PCV2b)-spreading Duroc pig population were investigated. The NOD2 allele (NOD2-2197A) with reduced recognition of the peptidoglycan components augmented the mortality of pigs at the growing stage in the PCV2b-spreading population. Comparison of NOD2 allele frequencies in the piglets before and after invasion of PCV2b indicated that the ratio of NOD2-2197A decreased in the population after the PCV2b epidemic. This data indicated that functional differences caused by NOD2-2197 polymorphisms have a marked impact on pig health and livestock productivity. We suggest that NOD2-2197CC is a PCV2 disease resistant polymorphism, which is useful for selective breeding by reducing mortality and increasing productivity.

中文翻译：

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NOD2 基因型影响猪圆环病毒 2 传播猪群的症状和死亡率

核苷酸寡聚结构域 (NOD) 样受体 2 (NOD2) 是一种细胞内模式识别受体，可检测细菌细胞壁中的肽聚糖成分。NOD2调节肠道微生物，提供对腹泻等感染的抵抗力，并降低人和小鼠患炎症性肠病的风险。我们之前证明了特定的猪NOD2多态性 ( NOD2 -2197A > C) 增强了对肽聚糖成分的识别。在这项研究中，研究了猪NOD2 -2197A/C 基因型在猪圆环病毒 2b (PCV2b) 传播的杜洛克猪群中影响分子功能和症状的关系。NOD2等位基因( NOD2-2197A) 随着对肽聚糖成分的识别减少，PCV2b 传播群体中生长期猪的死亡率增加。比较PCV2b 入侵前后仔猪NOD2等位基因频率表明，PCV2b 流行后群体中NOD2 -2197A 的比率降低。该数据表明，由NOD2 -2197 多态性引起的功能差异对猪健康和牲畜生产力具有显着影响。我们认为NOD2 -2197CC 是一种 PCV2 抗病多态性，可通过降低死亡率和提高生产力来进行选择性育种。