当前位置: X-MOL 学术Chem. Nat. Compd. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Two New Antibacterial Anthraquinones from Cultures of an Endophytic Fungus Phomopsis sp.
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-09-15 , DOI: 10.1007/s10600-021-03489-6
Fan Wu 1 , Ya-Ning Zhu 1 , Yu-Ting Hou 1 , Dong Miao 1 , Min Zhou 1 , Wei-Guang Wang 1 , Qiu-Fen Hu 1 , Yan-Qing Ye 1 , Qi-Li Mi 2 , Jian-Hua Chen 2 , Cheng-Ming Zhang 2 , Xue-Mei Li 2
Affiliation  

Two new anthraquinones, 3-hydroxy-6-hydroxymethyl-2,5-dimethylanthraquinone (1) and 6-hydroxymethyl-3-methoxy-2,5-dimethylanthraquinone (2), were isolated from the fermentation products of the endophytic fungus Phomopsis sp. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antimethicillin-resistant Staphylococcus aureus activity. The results showed that compounds 1 and 2 showed good inhibition with IZD of 14.2 ± 2.0 and 14.8 ± 2.2 mm, respectively. Compounds 1 and 2 were also tested for antioxidant activity; they show good activity with IC50 values of 4.18 and 4.36 μg/mL, respectively.



中文翻译:

来自内生真菌拟茎点霉菌培养物的两种新型抗菌蒽醌。

两个新的蒽醌,3-羟基-6-羟甲基-2,5- dimethylanthraquinone(1)和6-羟甲基-3-甲氧基-2,5-二dimethylanthraquinone(2),从该内生真菌的发酵产物中分离拟茎点霉属. 它们的结构是通过光谱方法阐明的,包括广泛的 1D 和 2D NMR 技术。评估了化合物 1 和 2 的抗甲氧西林金黄色葡萄球菌活性。结果表明,化合物1和2显示出良好的抑制作用,IZD分别为14.2±2.0和14.8±2.2mm。还测试了化合物 1 和 2 的抗氧化活性;它们显示出良好的活性,IC 50值分别为 4.18 和 4.36 μg/mL。

更新日期:2021-09-16
down
wechat
bug