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Two New Antibacterial Anthraquinones from Cultures of an Endophytic Fungus Phomopsis sp.

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Chemistry of Natural Compounds Aims and scope

Two new anthraquinones, 3-hydroxy-6-hydroxymethyl-2,5-dimethylanthraquinone (1) and 6-hydroxymethyl-3-methoxy-2,5-dimethylanthraquinone (2), were isolated from the fermentation products of the endophytic fungus Phomopsis sp. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antimethicillin-resistant Staphylococcus aureus activity. The results showed that compounds 1 and 2 showed good inhibition with IZD of 14.2 ± 2.0 and 14.8 ± 2.2 mm, respectively. Compounds 1 and 2 were also tested for antioxidant activity; they show good activity with IC50 values of 4.18 and 4.36 μg/mL, respectively.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (No. 21967021), the Foundation of Yunnan Tobacco Industry Co., Ltd. (No. 2019JC04), and the Foundation of Yunnan Innovative Research Team.

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, 650031, Kunming, P. R. China

    Fan Wu, Ya-Ning Zhu, Yu-Ting Hou, Dong Miao, Min Zhou, Wei-Guang Wang, Qiu-Fen Hu & Yan-Qing Ye

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Qi-Li Mi, Jian-Hua Chen, Cheng-Ming Zhang & Xue-Mei Li

Authors
  1. Fan Wu
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  2. Ya-Ning Zhu
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  3. Yu-Ting Hou
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  4. Qi-Li Mi
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  5. Jian-Hua Chen
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  6. Cheng-Ming Zhang
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  7. Dong Miao
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  8. Min Zhou
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  9. Wei-Guang Wang
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  10. Qiu-Fen Hu
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  11. Yan-Qing Ye
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  12. Xue-Mei Li
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Corresponding authors

Correspondence to Yan-Qing Ye or Xue-Mei Li.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 707–710.

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Wu, F., Zhu, YN., Hou, YT. et al. Two New Antibacterial Anthraquinones from Cultures of an Endophytic Fungus Phomopsis sp.. Chem Nat Compd 57, 823–827 (2021). https://doi.org/10.1007/s10600-021-03489-6

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  • DOI: https://doi.org/10.1007/s10600-021-03489-6

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