Chemical Constituents of the Roots of Phlomis betonicoides and Their Anti-Rotavirus Activity,Chemistry of Natural Compounds

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Chemical Constituents of the Roots of Phlomis betonicoides and Their Anti-Rotavirus Activity
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-09-15 , DOI: 10.1007/s10600-021-03499-4
Yu-Ting Hou _{1,

2} , Fan Wu _{1,

2} , Min Zhou ₁ , Yan-Qing Ye ₁ , Wei-Guang Wang ₁ , Guang-Yu Yang _{1,

2} , Qiu-Fen Hu ₁ , Ying Guan _{1,

2} , Jian-Hua Yao ₂ , Zhou-Hai Zhu ₂ , Qi-Li Mi ₂ , Qian Gao ₂

Affiliation

Two new isobenzofuranone derivatives (1 and 2) together with six known compounds (3–8) were isolated from the roots of Phlomis betonicoides, a highly sweet plant in China. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–8 were tested for their anti-rotavirus activity. The results showed that compounds 1–8 exhibited potent anti-rotavirus activity with therapeutic index value 7.5–16.4.

更新日期：2021-09-16

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