Two new isobenzofuranone derivatives (1 and 2) together with six known compounds (3–8) were isolated from the roots of Phlomis betonicoides, a highly sweet plant in China. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–8 were tested for their anti-rotavirus activity. The results showed that compounds 1–8 exhibited potent anti-rotavirus activity with therapeutic index value 7.5–16.4.
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Acknowledgment
This research was supported by the National Natural Science Foundation of China (Nos. 31560439 and 21762050), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (Grant to M.Z.), and the Yunnan Innovative Research Team for Discovery and Comprehensive Utilization of Functional Small Molecules in Medicinal Plants.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 739–742.
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Hou, YT., Wu, F., Yao, JH. et al. Chemical Constituents of the Roots of Phlomis betonicoides and Their Anti-Rotavirus Activity. Chem Nat Compd 57, 864–868 (2021). https://doi.org/10.1007/s10600-021-03499-4
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DOI: https://doi.org/10.1007/s10600-021-03499-4