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G1-like PB2 gene improves virus replication and competitive advantage of H9N2 virus
Virus Genes ( IF 1.9 ) Pub Date : 2021-09-14 , DOI: 10.1007/s11262-021-01870-9
Xiuli Li 1 , Shumiao Qiao 1 , Ying Zhao 1 , Min Gu 1 , Ruyi Gao 1 , Kaituo Liu 1 , Zhichuang Ge 1 , Jing Ma 1 , Xiaoquan Wang 1 , Jiao Hu 1 , Shunlin Hu 1 , Xiaowen Liu 1 , Sujuan Chen 1 , Daxin Peng 1 , Xiufan Liu 1, 2
Affiliation  

H9N2 subtype avian influenza virus has dramatically evolved and undergone extensive reassortment since its emergence in early 1990s in China. The genotype S (G57), emerging in 2007 with the substitution of F98-like PB2 and M gene by G1-like ones, has become the overwhelming predominant genotype for the past 11 years since 2010. Here, we found that virus with G1-like PB2 were more efficient in protein expression and in infectious virus production than that with F98-like PB2 gene. By coinfected MDCK cells with the reassortant virus, more survival opportunity for viruses with G1-like PB2 than that of F/98-like was observed. Besides, in animal experiments, we found that the G1-like PB2 increases virus infectivity, replication, and virus shedding of H9N2 in chickens. Our results suggested that the substitution of G1-like PB2 play important role in promoting the fitness of genotype S H9N2 virus in China.

更新日期:2021-09-15
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