For diagnosis of neuroborreliosis, calculation of the antibody index, based on Euroimmun Anti-Borrelia plus VlsE ELISA was compared to Virotech Borrelia Europe plus TpN17 immunoblot-based detection of Borrelia-specific intrathecal antibody production. CXCL13 results in cerebrospinal fluid were used to evaluate discordant results. A total of 64 serum/CSF pairs were analysed. Patients were classified according to European Federation of Neurological Societies criteria incorporating Virotech results. For the Euroimmun assay, a sensitivity of 100% and specificity of 94% was found. Agreement between the both tests was almost perfect (κ 0.81). Both methods are appropriate for the detection of Borrelia-specific intrathecal antibody production.

对于神经疏螺旋体病的诊断，将基于 Euroimmun Anti-Borrelia 加 VlsE ELISA 的抗体指数计算与 Virotech Borrelia Europe 加 TpN17 基于免疫印迹的疏螺旋体特异性鞘内抗体产生的检测进行比较。脑脊液中的 CXCL13 结果用于评估不一致的结果。分析了总共 64 对血清/CSF。根据纳入 Virotech 结果的欧洲神经学会标准对患者进行分类。对于 Euroimmun 测定，发现灵敏度为 100%，特异性为 94%。两个测试之间的一致性几乎是完美的（κ 0.81）。两种方法都适用于检测疏螺旋体特异性鞘内抗体的产生。