Abstract

Messenger RNA is complexed with proteins throughout its life cycle. The first mRNA-containing particles of non-ribosomal nature, named informosomes, were discovered in cytoplasmic extracts of fish embryos by the laboratory of Alexander Spirin, and later described in live cells. Over time, various other nuclear and cytoplasmic mRNA-containing ribonucleoproteins (mRNPs) have been found and characterized. Although these mRNPs are very diverse in their subcellular localization, structure and functions, they share many common characteristics with informosomes. In this mini-review, I will discuss the discovery of informosomes, their characteristics and proposed functions, and their potential relationship to other mRNPs.

中文翻译：

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Informosomes Travel in Time：当前 mRNP 格局中的早期 mRNA 概念

摘要

信使 RNA 在其整个生命周期中都与蛋白质复合。Alexander Spirin 实验室在鱼胚胎的细胞质提取物中发现了第一个非核糖体性质的 mRNA 颗粒，称为信息体，后来在活细胞中描述。随着时间的推移，已经发现并表征了各种其他含有核和细胞质 mRNA 的核糖核蛋白 (mRNP)。尽管这些 mRNP 在亚细胞定位、结构和功能方面非常多样化，但它们与信息体具有许多共同特征。在这篇简短的评论中，我将讨论信息体的发现、它们的特征和拟议的功能，以及它们与其他 mRNP 的潜在关系。