Advanced Fiber Materials ( IF 17.2 ) Pub Date : 2021-09-13 , DOI: 10.1007/s42765-021-00099-3 Yang Zhao 1 , Chuanrui Chen 1 , Tenglong Mei 1 , Lei Ye 1 , Liyuan Wang 1 , Yue Guo 1 , Xuemei Sun 1 , Huisheng Peng 1 , Yangyang Qiu 2 , Huan Feng 2 , Jiaxue Wu 2 , Ye Zhang 3
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Electrochemical therapy emerged as a low-cost and effective method for tumor ablation. However, it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft tissues. Here, we report a new injectable and tissue-compatible fiber therapeutic electronics for safe and efficient tumor treatment. The design of aligned carbon nanotube (CNT) fiber as electrodes endowed the device with high softness and enabled mini-invasive implantation through injection. Under a mild voltage (1.2 V), the fiber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases, leading to immediate death of tumor cells. The flexible fiber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 days. The in vitro experimental results showed the fiber device could efficiently kill 90.9% of QGY-7703 cancer cells after a single treatment in a few minutes. The tumor-bearing animal models proved that the fiber therapeutic device could effectively inhibit the growth of tumor tissues, indicating it is a safe, effective, controllable and low-cost method for tumor therapy.
Graphic Abstract
中文翻译：
用于肿瘤治疗的可注射光纤电子设备
电化学疗法是一种低成本且有效的肿瘤消融方法。然而，它面临着挑战，例如有毒副产品的产生和使用会损坏软组织的刚性电极。在这里，我们报告了一种新的可注射且与组织相容的纤维治疗电子设备，用于安全有效的肿瘤治疗。排列的碳纳米管（CNT）纤维作为电极的设计赋予了该装置高柔软度，并通过注射实现了微创植入。在温和的电压 (1.2 V) 下，纤维装置释放氢氧根离子来改变组织的局部化学环境，而不会产生额外的有毒产物/气体，导致肿瘤细胞立即死亡。柔性纤维装置可与组织形成稳定的界面，并在植入 30 天后显示出良好的生物相容性。体外实验结果表明，单次处理后，光纤装置可在几分钟内有效杀死 90.9% 的 QGY-7703 癌细胞。荷瘤动物模型证明，该纤维治疗器能有效抑制肿瘤组织的生长，是一种安全、有效、可控、低成本的肿瘤治疗方法。
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