Abstract—

This review discusses the possibilities of the method of layer-by-layer adsorption of polyelectrolytes on colloidal particles used to design the tools for drug delivery and the studies of recent years on designing the carriers based on the particles of lactide/glycolide copolymers and a polyelectrolyte capsule for targeted drug delivery. The examples of inclusion of functional substances in the core or multilayer coating of carriers, as well as formation of complex systems containing different target agents in the core and the coating, are presented. The effects of the composition of polyelectrolyte coating on the properties of resultant particles were considered. The prospects of modification of lactide/glycolide copolymer particles by the layer-by-layer adsorption of polyelectrolytes for the development of new tools for targeted drug delivery were demonstrated.

中文翻译：

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通过聚电解质的逐层吸附修饰基于丙交酯/乙交酯共聚物的粒子的可能性，以设计靶向药物递送工具

摘要——

本综述讨论了将聚电解质逐层吸附在胶体颗粒上的方法用于设计药物递送工具的可能性，以及近年来基于丙交酯/乙交酯共聚物颗粒和聚电解质设计载体的研究。用于靶向给药的胶囊。介绍了在载体的核心或多层涂层中包含功能性物质的例子，以及在核心和涂层中形成包含不同目标试剂的复杂系统的例子。考虑了聚电解质涂层的组成对所得颗粒性能的影响。