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Design and development of a photoswitchable DFG-out kinase inhibitor
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-07 , DOI: 10.1039/d1cc04125h Yongjin Xu 1 , Chunxia Gao 1 , Liliana Håversen 2 , Thomas Lundbäck 3 , Joakim Andréasson 4 , Morten Grøtli 1
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-07 , DOI: 10.1039/d1cc04125h Yongjin Xu 1 , Chunxia Gao 1 , Liliana Håversen 2 , Thomas Lundbäck 3 , Joakim Andréasson 4 , Morten Grøtli 1
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We report the synthesis and characterisation of a photoswitchable DFG-out kinase inhibitor. Photocontrol of the target kinase in both enzymatic and living cell assays is demonstrated.
中文翻译：
光开关DFG-out激酶抑制剂的设计与开发
我们报告了光开关 DFG-out 激酶抑制剂的合成和表征。证明了在酶促和活细胞测定中对靶激酶的光控制。
更新日期：2021-09-10
中文翻译：
光开关DFG-out激酶抑制剂的设计与开发
我们报告了光开关 DFG-out 激酶抑制剂的合成和表征。证明了在酶促和活细胞测定中对靶激酶的光控制。
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