Issue 78, 2021
From the journal:

Chemical Communications

Design and development of a photoswitchable DFG-out kinase inhibitor†

Yongjin Xu,a   Chunxia Gao,a   Liliana Håversen,b   Thomas Lundbäck, ORCID logo c   Joakim Andréasson ORCID logo *d  and  Morten Grøtli ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Molecular Biology, University of Gothenburg, SE-41296 Gothenburg, Sweden
E-mail: grotli@chem.gu.se

b Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, SE-41345 Gothenburg, Sweden

c Mechanistic & Structural Biology, Discovery Sciences, R&D, AstraZeneca, SE-48183 Mölndal, Sweden

d Department of Chemistry and Chemical Engineering, Physical Chemistry, Chalmers University of Technology, SE-41296 Gothenburg, Sweden
E-mail: a-son@chalmers.se

Abstract

We report the synthesis and characterisation of a photoswitchable DFG-out kinase inhibitor. Photocontrol of the target kinase in both enzymatic and living cell assays is demonstrated.

Graphical abstract: Design and development of a photoswitchable DFG-out kinase inhibitor

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Article information

DOI
https://doi.org/10.1039/D1CC04125H
Article type
Communication
Submitted
29 Jul 2021
Accepted
04 Sep 2021
First published
07 Sep 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 10043-10046

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Design and development of a photoswitchable DFG-out kinase inhibitor

Y. Xu, C. Gao, L. Håversen, T. Lundbäck, J. Andréasson and M. Grøtli, Chem. Commun., 2021, 57, 10043 DOI: 10.1039/D1CC04125H

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