Abstract

An efficient synthesis of fluorinated [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been achieved by cyclocondensation of 5-substituted 4-amino-1,2,4-triazole-3-thiols with fluoro-substituted aromatic acids using phosphoryl chloride as a cyclizing agent. The synthesized compounds were characterized by spectroscopic techniques, including IR, ¹H NMR, and mass spectra.

中文翻译：

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氟化[1,2,4]三唑并[3,4-b][1,3,4]噻二唑的高效合成

摘要

通过 5-取代 4-氨基-1,2,4-三唑-的环缩合实现了氟化[1,2,4]三唑并[3,4- b ][1,3,4]噻二唑衍生物的有效合成3-硫醇与氟取代的芳香酸使用磷酰氯作为环化剂。合成的化合物通过光谱技术表征，包括 IR、¹ H NMR 和质谱。