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Efficient Synthesis of Fluorinated [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles

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Abstract

An efficient synthesis of fluorinated [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been achieved by cyclocondensation of 5-substituted 4-amino-1,2,4-triazole-3-thiols with fluoro-substituted aromatic acids using phosphoryl chloride as a cyclizing agent. The synthesized compounds were characterized by spectroscopic techniques, including IR, 1H NMR, and mass spectra.

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Authors and Affiliations

  1. Department of Chemistry, Swami Vivekanand Senior College, 431504, Mantha, Maharashtra, India

    B. K. Dhotre & V. B. Jagrut

  2. Department of Chemistry, Maulana Azad College, 431001, Aurangabad, Maharashtra, India

    S. V. Raut & M. A. Pathan

  3. Navin Research and Innovation Centre, 395002, NFIL Surat, Gujarat, India

    M. A. Patharia

Authors
  1. B. K. Dhotre
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  2. S. V. Raut
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  3. V. B. Jagrut
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  4. M. A. Patharia
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  5. M. A. Pathan
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Contributions

Y.B. Kiran and G. Rambabu conceived the idea and performed experiments. V. Vijayakumar supported to get analytical data and involved in discussions. Y.B. Kiran prepared the manuscript, and L.C.A. Barbosa provided suggestions to improve the quality of the work and worked on the final version of the manuscript.

Corresponding author

Correspondence to B. K. Dhotre.

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No conflict of interest was declared by the authors.

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Dhotre, B.K., Raut, S.V., Jagrut, V.B. et al. Efficient Synthesis of Fluorinated [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles. Russ J Org Chem 57, 1135–1140 (2021). https://doi.org/10.1134/S1070428021070137

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  • DOI: https://doi.org/10.1134/S1070428021070137

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