The evidence shows that individuals with type-1 diabetes mellitus (T1DM) are at greater risk of accelerated cognitive impairment and dementia. Although, to date the mechanisms are largely unknown. An emerging body of literature indicates that dysfunction of cerebral neurovascular network and plasma dyshomeostasis of soluble amyloid-β in association with impaired lipid metabolism are central to the onset and progression of cognitive deficits and dementia. However, the latter has not been extensively considered in T1DM. Therefore, in this review, we summarised the literature concerning altered lipid metabolism and cerebrovascular function in T1DM as an implication for potential pathways leading to cognitive decline and dementia.

证据表明，患有 1 型糖尿病 (T1DM) 的人患加速认知障碍和痴呆的风险更大。虽然，迄今为止，机制在很大程度上是未知的。新出现的文献表明，脑神经血管网络功能障碍和可溶性β-淀粉样蛋白的血浆稳态失调与脂质代谢受损有关，是认知缺陷和痴呆的发生和进展的核心。然而，后者尚未在 T1DM 中得到广泛考虑。因此，在这篇综述中，我们总结了有关 T1DM 中脂质代谢和脑血管功能改变的文献，作​​为导致认知能力下降和痴呆的潜在途径的暗示。