Background

Chronic kidney disease (CKD) is condition characterized by a gradual loss of kidney function, patient with CKD suffering from a variety of immune system defects.

Methods

This study looked at Fas, T cell, BCl2, and P53 activity in people with CKD, end stage renal disease (ESRD), and stable controls.

Results

The CD4+ and CD8+ levels in ESRD patients’ peripheral blood were slightly lower than those in CKD patients. The CKD and ESRD groups had slightly higher Fas and FasL mRNA expression and slightly lower BCl2 mRNA gene expression than the normal control group (P < 0.05). P53 mRNA gene expression was shown to be higher in the patients than in the controls (P < 0.01).

Conclusions

ESRD patients have a significantly lower number of T-cell subsets than CKD patients this is related to a higher degree of apoptosis in these cells.

中文翻译：

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慢性肾病和终末期肾病患者的炎症标志物

背景

慢性肾脏病 (CKD) 是一种以肾功能逐渐丧失为特征的疾病，患有 CKD 的患者患有各种免疫系统缺陷。

方法

这项研究着眼于 CKD、终末期肾病 (ESRD) 和稳定对照组患者的 Fas、T 细胞、BCl2 和 P53 活性。

结果

ESRD患者外周血CD4+、CD8+水平略低于CKD患者。CKD和ESRD组Fas和FasL mRNA表达略高于正常对照组，BCl2 mRNA表达略低于正常对照组（P < 0.05）。患者的 P53 mRNA 基因表达水平高于对照组（P < 0.01）。

结论

ESRD 患者的 T 细胞亚群数量明显低于 CKD 患者，这与这些细胞中更高程度的细胞凋亡有关。