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Inflammatory markers in chronic kidney disease and end stage renal disease patients

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Abstract

Background

Chronic kidney disease (CKD) is condition characterized by a gradual loss of kidney function, patient with CKD suffering from a variety of immune system defects.

Methods

This study looked at Fas, T cell, BCl2, and P53 activity in people with CKD, end stage renal disease (ESRD), and stable controls.

Results

The CD4+ and CD8+ levels in ESRD patients’ peripheral blood were slightly lower than those in CKD patients. The CKD and ESRD groups had slightly higher Fas and FasL mRNA expression and slightly lower BCl2 mRNA gene expression than the normal control group (P < 0.05). P53 mRNA gene expression was shown to be higher in the patients than in the controls (P < 0.01).

Conclusions

ESRD patients have a significantly lower number of T-cell subsets than CKD patients this is related to a higher degree of apoptosis in these cells.

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Data availability

The datasets used during the present study are available from the corresponding author on reasonable request.

Abbreviations

CKD:

Chronic kidney disease

ESRD:

End-stage renal disease

GFR:

Glomerular filtration rate

CRP:

C-reactive protein

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Funding

This research received no external funding.

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Authors and Affiliations

  1. Faculty of Medicine, Urology and Nephrology Center, Mansoura University, Mansoura, 35511, Egypt

    Mahmoud M. Zakaria, Safaa A. Derbala, Amgad E. EL-Agroudy & Fatma M. El-Tantawy

  2. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt

    Ayman E. Salem

Authors
  1. Mahmoud M. Zakaria
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  2. Safaa A. Derbala
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  3. Ayman E. Salem
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  4. Amgad E. EL-Agroudy
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  5. Fatma M. El-Tantawy
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Contributions

MMZ and SAD contributed to conception and design of the study. FME-T and SAD and AES, contributed to acquisition, analysis and interpretation of the data and writing the manuscript. MMZ, AEE-A and FME-T discussed the results and implications and commented on the manuscript at all stages, as well as in the final approval of the version to be published.

Corresponding author

Correspondence to Fatma M. El-Tantawy.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies were in accordance with ethics standards of Mansoura University, Faculty of Medicine. We commit to provide Photocopy of consent forms of all subjects involved to the ethical committee when requested before publishing or submitting to refereeing.

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Zakaria, M.M., Derbala, S.A., Salem, A.E. et al. Inflammatory markers in chronic kidney disease and end stage renal disease patients. Mol Biol Rep 48, 6857–6862 (2021). https://doi.org/10.1007/s11033-021-06684-4

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  • DOI: https://doi.org/10.1007/s11033-021-06684-4

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