Acinetobacter baumannii has become a major concern for scientific attention due to extensive antimicrobial resistance. This resistance causes an increase in mortality rate because strains resistant to antimicrobial agents are a major challenge for physicians and healthcare workers regarding the eradication of either hospital or community-based infections. These strains with emerging resistance are a serious issue for patients in the intensive care unit (ICU). Antibiotic resistance has increased because of the acquirement of mobile genetic elements such as transposons, plasmids, and integrons and causes the prevalence of multidrug resistance strains (MDR). In addition, an increase in carbapenem resistance, which is used as last line antibiotic treatment to eliminate infections with multidrug-resistant Gram-negative bacteria, is a major concern. Carbapenems resistant A. baumannii (CR-Ab) is a worldwide problem. Because these strains are often resistant to all other commonly used antibiotics. Therefore, pathogenic multi-drug resistance A. baumannii (MDR-Ab) associated infections become hard to eradicate. Plasmid-mediated resistance causes outbreaks of extensive drug-resistant. A. baumannii (XDR-Ab). In addition, recent outbreaks relating to livestock and community settings illustrate the existence of large MDR-Ab strain reservoirs within and outside hospital settings. The purpose of this review, proper monitoring, prevention, and treatment are required to control (XDR-Ab) infections. Attachment, the formation of biofilms and the secretion of toxins, and low activation of inflammatory responses are mechanisms used by pathogenic A. baumannii strain. This review will discuss some aspects associated with antibiotics resistance in A. baumannii as well as cover briefly phage therapy as an alternative therapeutic treatment.

由于广泛的抗菌药物耐药性，鲍曼不动杆菌已成为科学界关注的主要问题。这种耐药性导致死亡率增加，因为对抗菌药物耐药的菌株是医生和医护人员在根除医院或社区感染方面面临的主要挑战。这些出现耐药性的菌株对于重症监护病房 (ICU) 的患者来说是一个严重的问题。由于转座子、质粒和整合子等可移动遗传元件的获得，抗生素耐药性有所增加，并导致多药耐药菌株（MDR）的流行。此外，碳青霉烯类耐药性的增加也是一个主要问题，碳青霉烯类抗生素被用作消除多重耐药革兰氏阴性菌感染的最后一线抗生素治疗。耐碳青霉烯类鲍曼不动杆菌(CR-Ab) 是一个世界性问题。因为这些菌株通常对所有其他常用抗生素具有耐药性。因此，致病性多药耐药鲍曼不动杆菌（MDR-Ab）相关感染变得难以根除。质粒介导的耐药性导致广泛耐药性的爆发。鲍曼不动杆菌（XDR-Ab）。此外，最近与牲畜和社区环境有关的疫情暴发表明，医院环境内外存在大型耐多药抗体菌株储存库。本次审查的目的是控制（XDR-Ab）感染需要适当的监测、预防和治疗。附着、生物膜的形成和毒素的分泌以及炎症反应的低激活是致病性鲍曼不动杆菌菌株使用的机制。 本综述将讨论与鲍曼不动杆菌抗生素耐药性相关的一些方面，并简要介绍噬菌体疗法作为替代治疗方法。