Purpose

Limited studies have been published on the association between the urinary biomarkers of Polycyclic Aromatic Hydrocarbons (PAHs) and risk of Metabolic Syndromes (MetS) and blood cell levels in adults in the Middle East. The present study aimed to evaluate the exposure to PAHs and the distribution of urinary OH-PAH levels in the general population of Shiraz, Iran, as well as, the association between OH-PAHs and the prevalence of MetS and blood cell levels.

Methods

In this study, 200 participants were randomly selected from the adult population, and their first-morning void urine samples were collected.

Results

The mean concentrations of 1-OHNap, 2-OHNap, 2-OHFlu, 9-OHPhe, and 1-OHP were 639.8, 332.1, 129, 160.3, and 726.9 ng/g creatinine, respectively. The prevalence of MetS was 26% according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The results showed that urinary OH-PAHs, especially 1-OHP, were positively and significantly associated with higher waist circumstance (p < 0.001), triglyceride level (p < 0.001), systolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.001), number of white blood cells (p = 0.041) and red blood cells (p < 0.001). It also caused lower levels of High Density Lipoprotein-Cholesterol (HDL-C). In conclusion, the results emphasized the adverse health effects of PAHs on human health, including obesity, hypertension, dyslipidemia, and decreased number of blood cells.

Conclusion

Therefore, in order to identify the PAHs sources and to develop methods for decreasing the amount of emissions to the environment, broader researches are needed.

中文翻译：

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中东地区成人多环芳烃尿生物标志物与代谢综合征风险和血细胞水平之间的关联

目的

关于多环芳烃 (PAHs) 的尿液生物标志物与中东成人代谢综合征 (MetS) 风险和血细胞水平之间关联的研究有限。本研究旨在评估伊朗设拉子普通人群中 PAHs 的暴露情况和尿中 OH-PAH 水平的分布，以及 OH-PAHs 与 MetS 的患病率和血细胞水平之间的关系。

方法

在这项研究中，从成年人群中随机选择了 200 名参与者，并收集了他们的第一天晨尿样本。

结果

1-OHNap、2-OHNap、2-OHFlu、9-OHPhe 和 1-OHP 的平均浓度分别为 639.8、332.1、129、160.3 和 726.9 ng/g 肌酐。根据国家胆固醇教育计划成人治疗小组 III (NCEP-ATP III) 标准，MetS 的患病率为 26%。结果表明，尿 OH-PAHs，尤其是 1-OHP，与腰围较高（p < 0.001）、甘油三酯水平（p < 0.001）、收缩压（p < 0.001）、舒张压（ p < 0.001)、白细胞数 (p = 0.041) 和红细胞数 (p < 0.001)。它还导致低水平的高密度脂蛋白胆固醇 (HDL-C)。总之，结果强调了 PAHs 对人类健康的不利健康影响，包括肥胖、高血压、血脂异常、

结论

因此，为了确定 PAHs 的来源并开发减少环境排放量的方法，需要进行更广泛的研究。