Colloid and Polymer Science ( IF 2.2 ) Pub Date : 2021-08-27 , DOI: 10.1007/s00396-021-04885-8 Jun Zhong 1 , Kai Sun 1 , Bingbing Wang 2 , Jiang Duan 2
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Hyperbranched polyethylenimines (hPEIs) have diverse biological applications; however, the intrinsic toxicity is a major concern in developing hPEI-based biomaterials. This work reports the synthesis, properties, and an application as a biocompatible hPEI-based material, namely, fluorescent oxidized hPEI polymeric nanoparticles (F-ohPEIs). The synthesis was achieved through oxidation of hPEI with H2O2 and subsequent cross-linking with formaldehyde, imparting to F-ohPEIs’ desired properties such as remarkably reduced positive charge density, hydrolytic degradability, low cytotoxicity, strong fluorescence emission, and stability. Furthermore, as an application, F-ohPEI demonstrated the ability to selectively respond to cupric ion in a wide concentration range of 0.02 ~ 10 μM with a low limit of detection of 0.013 μM. The synthesis strategy along with the F-ohPEI nanoparticles developed in this work is expected to find promising application in fabricating biocompatible hPEI-based biomaterials.
Graphical abstract
中文翻译：
超支化聚乙烯亚胺基聚合物纳米粒子：合成、性质和对铜离子选择性响应的应用
超支化聚乙烯亚胺 (hPEI) 具有多种生物学应用；然而，内在毒性是开发基于 hPEI 的生物材料的主要问题。这项工作报告了合成、性质和作为生物相容性 hPEI 基材料的应用，即荧光氧化 hPEI 聚合物纳米粒子 (F-ohPEI)。合成是通过用 H 2 O 2氧化 hPEI 实现的随后与甲醛交联，赋予 F-ohPEI 所需的特性，例如显着降低正电荷密度、水解降解性、低细胞毒性、强荧光发射和稳定性。此外，作为应用，F-ohPEI 展示了在 0.02 ~ 10 μM 的宽浓度范围内选择性响应铜离子的能力，检测下限为 0.013 μM。在这项工作中开发的 F-ohPEI 纳米粒子的合成策略有望在制造生物相容性 hPEI 生物材料中找到有希望的应用。
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