This study aimed to investigate the antioxidant and protective effect of E. persicus leaf hydroalcoholic extract (EPE) in preventing gastric ulcers induced by ethanol in rats. Wistar rats weighing 180–220 g were randomly divided into five groups. These groups included negative control (normal) group, positive control (ethanolic) group, comparative control (ranitidine recipient) group, group recipient the dose of 250 mg/kg plant extract, and group recipient the dose of 500 mg/kg plant extract. One hour after gavage of the drug and extract, the gastric ulcer was induced by feeding 1 ml of 96% ethanol to each animal except the rats of the negative control group. After one hour, the rats were killed, and their stomachs were separated. Then, the gastric Ulcer index (UI), pH, oxidative stress parameters, and histopathological changes in the stomach of all groups were measured. Pre-treatment of ethanol-induced rats with the EPE reduced (P < 0.05) the ulcer index and gastric juice pH, compared to ethanolic group rats. Furthermore, pre-treatment with EPE at a dose-dependent manner, alleviated the gastric oxidative stress injury in rats through increase the activity of CAT, tissue NO^· and GSH levels. EPE also was able to decrease the levels of ROS, MDA, PCO and serum NO^·. According to the results, it can be concluded that pre-treatment with EPE prevents the formation of gastric ulcers caused by ethanol, which can be attributed to the antioxidant activity of plant polyphenols compounds.

本研究旨在探讨E. persicus的抗氧化和保护作用叶水醇提取物 (EPE) 可预防大鼠乙醇引起的胃溃疡。体重为 180-220 克的 Wistar 大鼠被随机分为 5 组。这些组包括阴性对照（正常）组、阳性对照（乙醇）组、比较对照（雷尼替丁受体）组、250mg/kg植物提取物剂量的受体组和500mg/kg植物提取物剂量的受体组。灌胃药物和提取物1小时后，除阴性对照组大鼠外，每只动物喂食1ml 96％乙醇，诱发胃溃疡。一小时后，老鼠被杀死，它们的胃被分开。然后测量各组胃溃疡指数（UI）、pH、氧化应激参数和胃组织病理学变化。用 EPE 预处理乙醇诱导的大鼠可降低 (P  < 0.05) 与乙醇组大鼠相比，溃疡指数和胃液 pH 值。此外，EPE以剂量依赖性方式预处理，通过增加CAT活性、组织NO ^·和GSH水平来减轻大鼠胃氧化应激损伤。EPE还能够降低ROS、MDA、PCO和血清NO ^·的水平。根据结果​​，可以得出结论，用 EPE 预处理可防止乙醇引起的胃溃疡的形成，这可归因于植物多酚化合物的抗氧化活性。