This article presents a thermal sintering method to fabricate porous bone tissue engineering scaffolds based on polycaprolactone (PCL), polylactic acid (PLA), and their composites. The mechanical properties, porous structure, biodegradability, and biocompatibility of sintered scaffolds were evaluated. The scaffolds showed a porosity in the range of 86–91% with a pore size of 75 m\(\mu\) to 400 m\(\mu\). PCL/PLA composite scaffolds showed a Young’s modulus of around 49 MPa, which was between the modulus values of PCL (24 MPa) and PLA (63 MPa) scaffolds. Fibroblast cells (SNL) exhibited spreading and adhesion on the scaffolds, and scaffolds demonstrated a significant difference in the osteogenic differentiation of human mesenchymal stem cells (hMSCs) after 7 and 14 days of culture in comparison with the control (tissue culture polystyrene). Our results demonstrated that the thermally sintered PCL/PLA composite scaffold could be a promising candidate for bone tissue regeneration.

本文提出了一种基于聚己内酯 (PCL)、聚乳酸 (PLA) 及其复合材料的热烧结方法来制造多孔骨组织工程支架。对烧结支架的力学性能、多孔结构、生物降解性和生物相容性进行了评估。支架的孔隙率为 86-91%，孔径为 75 m \(\mu\)到 400 m \(\mu\). PCL/PLA 复合支架的杨氏模量约为 49 MPa，介于 PCL (24 MPa) 和 PLA (63 MPa) 支架的模量值之间。成纤维细胞 (SNL) 在支架上表现出扩散和粘附，与对照（组织培养聚苯乙烯）相比，在培养 7 天和 14 天后，支架在人类间充质干细胞 (hMSC) 的成骨分化方面表现出显着差异。我们的结果表明，热烧结 PCL/PLA 复合支架可能是骨组织再生的有希望的候选者。