Abstract

The aim of the work was to study changes in the time range of heart rate variability (HRV) against the background of changes in the concentration of corticosterone in blood plasma in rats after surgical trauma to the nasal septum. Septoplasty was simulated in 30 mature male Wistar rats weighing 210–290 g. ECG was recorded with subsequent analysis of the time domain of HRV, as well as blood sampling to estimate changes in the concentration of corticosterone in the blood plasma was performed. As a result, SDNN significantly increased in comparison with the control on days 2 and 3 (p < 0.001) but decreased on days 4–5 (p < 0.001) and 6 (p < 0.01). rMSSD changed in waves with two irregular peaks on days 1 and 6. SDNN/rMSSD, in comparison with the 1st day of the postoperative period, increased on the 2nd day, continued to increase (p < 0.05), and then began to decrease on day 4 (p < 0.01). The total HRV power of was low throughout the postoperative period (p < 0.001), except for day 3, when it was equal to the control data. The increase in the total power index fell on day 3 after the operation (p <0.01), after which its decline was observed again. The concentration of corticosterone in the blood plasma in rats was significantly higher than before (p < 0.001). On postoperative day 2 to 4, its plateau was determined. Simulation of septoplasty leads to changes in the time range of HRV, an increase in the concentration of corticosterone in the blood plasma in rats with its maximum at the time of surgery and 24 h later, and the formation of a “plateau” on postoperative days 2 to 4, which coincides with the changes in HRV.

中文翻译：

---

大鼠鼻中隔手术创伤后心率变异性和皮质酮的时域变化

 抽象的

这项工作的目的是研究鼻中隔手术创伤后大鼠血浆中皮质酮浓度变化背景下心率变异性 (HRV) 时间范围的变化。在 30 只体重为 210-290 克的成熟雄性 Wistar 大鼠中模拟鼻中隔成形术。记录心电图并随后分析 HRV 时域，并进行血液采样以估计血浆中皮质酮浓度的变化。结果，与对照组相比，SDNN 在第 2 天和第 3 天显着增加 ( p < 0.001)，但在第 4-5 天 ( p < 0.001) 和第 6 天 ( p < 0.01) 下降。 rMSSD 在第 1 天和第 6 天呈波状变化，有两个不规则的峰值。SDNN/rMSSD 与术后第 1 天相比，第 2 天增加，继续增加（p < 0.05），然后开始减少第 4 天（ p < 0.01）。整个术后期间的总 HRV 功效较低 ( p < 0.001)，但第 3 天除外，此时与对照数据相同。操作后第3天总功率指数增幅回落( p <0.01)，之后再次出现下降。大鼠血浆中皮质酮的浓度显着高于之前( p < 0.001)。术后第2天至第4天，确定其平台期模拟鼻中隔成形术导致HRV时间范围的变化，大鼠血浆中皮质酮浓度增加，在手术时和24小时后达到最大值，术后第2至4天形成“平台”，与HRV的变化一致。