Abstract
The aim of the work was to study changes in the time range of heart rate variability (HRV) against the background of changes in the concentration of corticosterone in blood plasma in rats after surgical trauma to the nasal septum. Septoplasty was simulated in 30 mature male Wistar rats weighing 210–290 g. ECG was recorded with subsequent analysis of the time domain of HRV, as well as blood sampling to estimate changes in the concentration of corticosterone in the blood plasma was performed. As a result, SDNN significantly increased in comparison with the control on days 2 and 3 (p < 0.001) but decreased on days 4–5 (p < 0.001) and 6 (p < 0.01). rMSSD changed in waves with two irregular peaks on days 1 and 6. SDNN/rMSSD, in comparison with the 1st day of the postoperative period, increased on the 2nd day, continued to increase (p < 0.05), and then began to decrease on day 4 (p < 0.01). The total HRV power of was low throughout the postoperative period (p < 0.001), except for day 3, when it was equal to the control data. The increase in the total power index fell on day 3 after the operation (p <0.01), after which its decline was observed again. The concentration of corticosterone in the blood plasma in rats was significantly higher than before (p < 0.001). On postoperative day 2 to 4, its plateau was determined. Simulation of septoplasty leads to changes in the time range of HRV, an increase in the concentration of corticosterone in the blood plasma in rats with its maximum at the time of surgery and 24 h later, and the formation of a “plateau” on postoperative days 2 to 4, which coincides with the changes in HRV.
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REFERENCES
Pustovit, O.M., Nasedkin, A.N., Egorov, V.I., Isa-ev, V.M., Isaev, E.V., and Morozov, I.I., Influence of ultrasonic cavitation and photochromotherapy on the process of reparation of the nasal mucosa after septoplasty and submucous vasotomy of the inferior turbinates, Head Neck. Russ. J., 2018, vol. 6, no. 2, pp. 20–26.
Van Egmond, M.M.H.T., Rovers, M.M., Hannink, G., Hendriks, C.T.M., and van Heerbeek, N., Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: a pragmatic, randomised controlled trial, Lancet, vol. 394, no. 10195, pp. 314–321.
Siegel, N.S., Gliklich, R.E., Taghizadeh, F., and Chang, Y., Outcomes of septoplasty, Otolaryngol. Head Neck Surg., 2000, vol. 122, no. 2, pp. 228–232.
Torshin, V., Kastyro, I., Kostyaeva, M., Popadyuk, V., Ermakova, N., Surovtsev, V., Gushchina, Y., and Kovalenko, A., The effect of destruction of the mucous membrane of the olfactory zone of the nasal septum on the cytoarchitectonics of the pyramidal layer of the hippocampus, Virchows Archiv., 2020, vol. 477, p. 340.
Kastyro, I.V., Reshetov, I.V., Khamidulin, G.V., Shmaevsky, P.E., Karpukhina, O.V., Inozemtsev, A.N., Torshin, V.I., Ermakova, N.V., and Popadyuk, V.I., The effect of surgical trauma in the nasal cavity on the behavior in the open field and the autonomic nervous system of rats, Dokl. Biochem. Biophys., 2020, vol. 492, pp. 121–123.
Kastyro, I.V., Reshetov, I.V., Khamidulin, G.V., Shi-lin, S.S., Torshin, V.I., Kostyaeva, M.G., Popadyuk, V.I., Yunusov, T.Y., Shmaevsky, P.E., Shalamov, K.P., Kupryakova, A.D., Doroginskaya, E.S., and Sedelniko-va, A.D., Influence of surgical trauma in the nasal cavity on the expression of p53 protein in the hippocampus of rats, Dokl. Biochem. Biophys., 2021, vol. 497, pp. 99–103.
Koenig, J. and Thayer, J.F., Sex differences in healthy human heart rate variability: a meta-analysis, Neurosci. Biobehav. Rev., 2016, vol. 64, pp. 288–310.
Sztajzel, J., Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system, Swiss Med. Wkly, 2004, vol. 134, pp. 514–522.
Kang, J.H., Kim, J.K., Hong, S.H., Lee, C.H., and Choi, B.Y., Heart rate variability for quantification of autonomic dysfunction in fibromyalgia, Ann. Rehabil. Med., 2016, vol. 40, no. 2, pp. 301–309.
Desborough, J.P., The stress response to trauma and surgery, Br. J. Anaesth., 2000, vol. 85, no. 1, pp. 109–117.
Kastyro, I.V., Torshin, V.I., Drozdova, G.A., and Popadyuk, V.I., Acute pain intensity in men and women after septoplasty, Russ. Open Med. J., 2017, vol. 6, no. 3, pp. 1–6.
Karri, J., Zhang, L., Li, S., Chen, Y.-T., Stampas, A., and Li, S., Heart rate variability: a novel modality for diagnosing neuropathic pain after spinal cord injury, Front. Physiol., 2017, vol. 8, p. 495.
Patural, H., Pichot, V., Flori, S., Giraud, A., Franco, P., Pladys, P., Beuchee, A., Roche, F., and Barthele-my, J.-C., Autonomic maturation from birth to 2 years: normative values, Heliyon, 2019, vol. 5, e01300.
Pagani, M., Lombardi, F., Guzzetti, S., Sandrone, G., Rimoldi, O., and Malfatto, G., Power spectral density of heart rate variability as an index of sympatho-vagal interaction in normal and hypertensive subjects, J. Hypertens. Suppl., 1984, vol. 2, pp. 383–385.
Valentino, R.J., Foote, S.L., and Aston-Jones, G., Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus, Brain Res., 1983, vol. 2, no. 270, pp. 363–367.
Gostyukhina A.A., Samoshchina T.A., Caitsev K.V., Gutor S.S., Zhukova O.B., Svetlik M.V., Abdulkina N.G., and Saitsev A.A., Adaptive responses of rats after light desynchronosis and physical fatigue, Byull. Sib. Med., 2018, vol. 17, no. 3, pp. 22–34.
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Experiments with animals were approved by the Bioethical Committee of the Sechenov First Moscow State Medical University, minutes no. 6 dated February 16, 2021.
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Kastyro, I.V., Popadyuk, V.I., Reshetov, I.V. et al. Changes in the Time-Domain of Heart Rate Variability and Corticosterone after Surgical Trauma to the Nasal Septum in Rats. Dokl Biochem Biophys 499, 247–250 (2021). https://doi.org/10.1134/S1607672921040098
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DOI: https://doi.org/10.1134/S1607672921040098