Objective

Recent data have shown that regular exercise may ameliorate motor symptoms in Parkinson’s disease (PD). This study aims to investigate how intended exercise impacts motor and non-movement symptoms of PD.

Methods

Eighty-eight patients were randomly assigned to an early exercise group (E-EG), late exercise group (L-EG), or a control group (CG) using a randomized delayed-start design. The E-EG carried out a rigorous, formal exercise program for 1 h, twice per week, for 18 months (May 2018–November 2019). The L-EG took part in the exercise program in the final 6–12 months of the study. We assessed outcomes using the Unified Parkinson’s Disease Rating Scale (UPDRS), PDQ-39 Questionnaire, Line A test, Line B test, Nine-hole column test, 30 s squat and stand-up test (30 s SST), 10-m walk test (10mW), Balance Evaluation Systems Mini Test (MiniBESTest), FAB, and Time Up and Go Test (TUG).

Results

The patients with PD in the E-EG had lower performance in the UPDRS and Line B test compared to those in the L-EG at post-exercise (p < 0.05). Moreover, the patients with PD in the E-EG had much lower performance in the PDQ-39 and 9-Hole Peg test compared to those in the L-EG at post-exercise (p < 0.01).

Conclusion

Implementation of an exercise regimen improved the movement abilities and quality of life in PD patients, especially in the E-EG. This data supports the idea that intended exercise should be implemented as part of the treatment strategy for PD patients as early as possible.

中文翻译：

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早期实施有针对性的运动可改善帕金森病患者的生活质量

目标

最近的数据表明，定期锻炼可能会改善帕金森病 (PD) 的运动症状。本研究旨在调查有计划的运动如何影响 PD 的运动和非运动症状。

方法

88 名患者被随机分配到早期运动组 (E-EG)、晚期运动组 (L-EG) 或使用随机延迟开始设计的对照组 (CG)。E-EG 进行了严格、正式的锻炼计划，每次 1 小时，每周两次，持续 18 个月（2018 年 5 月至 2019 年 11 月）。L-EG 在研究的最后 6-12 个月参加了锻炼计划。我们使用统一帕金森病评定量表 (UPDRS)、PDQ-39 问卷、A 线测试、B 线测试、九孔柱测试、30 秒深蹲和站立测试 (30 秒 SST)、10 米评估结果步行测试 (10mW)、平衡评估系统迷你测试 (MiniBESTest)、FAB 和 Time Up and Go Test (TUG)。

结果

与运动后的 L-EG 患者相比，E-EG 中的 PD 患者在 UPDRS 和 Line B 测试中的表现较低（p  < 0.05）。此外，与运动后 L-EG 患者相比，E-EG PD 患者在 PDQ-39 和 9 孔 Peg 测试中的表现要低得多（p  < 0.01）。

结论

运动方案的实施提高了 PD 患者的运动能力和生活质量，尤其是 E-EG。该数据支持应尽早将预期锻炼作为 PD 患者治疗策略的一部分的观点。