In the context of peripheral nerve injuries treatment, self-electrical stimuli nerve guidance conduit is a promising technique. To fabricate such structures, PVDF-chitosan–gelatin was considered for the outside walls of conduit and gellan gum containing conductive polyaniline-graphene (PAG) nanocomposite particles in the middle. PVDF-chitosan–gelatin nanofibers were prepared using the dual-electrospinning method and highly conductive binary-doped polyaniline-graphene was synthesized by chemical oxidative polymerization in the presence of aniline and sodium dodecyl sulfate. The morphology and chemical structure of nanofibers and PAG were characterized using SEM and FTIR analyses. The morphological, structural, electrical, and mechanical properties of gellan containing PAG particles were investigated with SEM, FTIR, piezoelectric and rheology tests. Gelation time, swelling, and degradation of gellan PAG were also studied. Morphological investigation of self-electrical stimuli conduit represents successful electrospinning and the polymerization of polyaniline was confirmed using FTIR and XRD methods. The designed conduit shows the adequate output voltage and highly oriented pore structures in gellan gel as an in-situ thermosensitive construction makes convenient properties for peripheral nerve injury treatment. Our obtained results illustrate that the self-electrical nerve guidance conduit with gellan PAG can provide a novel substrate as a neural conduit.

在周围神经损伤治疗的背景下，自电刺激神经引导导管是一种很有前途的技术。为了制造这样的结构，PVDF-壳聚糖-明胶被考虑用于导管的外壁和中间含有导电聚苯胺-石墨烯（PAG）纳米复合颗粒的结冷胶。PVDF-壳聚糖-明胶纳米纤维采用双静电纺丝法制备，并在苯胺和十二烷基硫酸钠存在下通过化学氧化聚合合成高导电二元掺杂聚苯胺-石墨烯。使用 SEM 和 FTIR 分析表征纳米纤维和 PAG 的形态和化学结构。用 SEM、FTIR、压电和流变测试研究了含有 PAG 颗粒的结冷胶的形态、结构、电学和机械性能。还研究了结冷胶 PAG 的胶凝时间、溶胀和降解。自电刺激导管的形态学研究代表了成功的静电纺丝，并且使用 FTIR 和 XRD 方法证实了聚苯胺的聚合。设计的导管在结冷胶中显示出足够的输出电压和高度定向的孔结构，因为原位热敏结构为周围神经损伤治疗提供了便利的特性。我们获得的结果表明，带有结冷胶 PAG 的自电神经引导导管可以提供一种新的基底作为神经导管。自电刺激导管的形态学研究代表了成功的静电纺丝，并且使用 FTIR 和 XRD 方法证实了聚苯胺的聚合。设计的导管在结冷胶中显示出足够的输出电压和高度定向的孔结构，因为原位热敏结构为周围神经损伤治疗提供了便利的特性。我们获得的结果表明，带有结冷胶 PAG 的自电神经引导导管可以提供一种新的基底作为神经导管。自电刺激导管的形态学研究代表了成功的静电纺丝，并且使用 FTIR 和 XRD 方法证实了聚苯胺的聚合。设计的导管在结冷胶中显示出足够的输出电压和高度定向的孔结构，因为原位热敏结构为周围神经损伤治疗提供了便利的特性。我们获得的结果表明，带有结冷胶 PAG 的自电神经引导导管可以提供一种新的基底作为神经导管。