The nucleoside antibiotic angustmycin, produced by some Streptomyces strains, is composed of adenine and C₆ sugar and shows antibiotic and antitumor activities. In this study, we propose a biosynthetic pathway for angustmycin using a heterologous expression experiment coupled with in silico analysis of the angustmycin biosynthetic gene (agm) cluster. The biochemical characterization of Agm6 demonstrated its role in angustmycin biosynthesis as an unprecedented dehydratase.

中文翻译：

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核苷抗生素安格斯霉素的生物合成：生物合成基因簇的鉴定和表征揭示了外切糖形成所需的前所未有的脱水酶

某些链霉菌属菌株产生的核苷类抗生素安格斯霉素由腺嘌呤和 C ₆糖组成，具有抗生素和抗肿瘤活性。在这项研究中，我们提出了利用在angustmycin生物合成基因（的计算机分析加上异源表达实验中生物合成途径angustmycin AGM）集群。Agm6 的生化特征表明其在安格斯霉素生物合成中的作用是一种前所未有的脱水酶。