Generic acquisition protocol for quantitative MRI of the spinal cord,Nature Protocols

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Generic acquisition protocol for quantitative MRI of the spinal cord
Nature Protocols ( IF 13.1 ) Pub Date : 2021-08-16 , DOI: 10.1038/s41596-021-00588-0
Julien Cohen-Adad _{1,

2,

3} , Eva Alonso-Ortiz ₁ , Mihael Abramovic ₄ , Carina Arneitz ₄ , Nicole Atcheson ₅ , Laura Barlow ₆ , Robert L Barry _{7,

8,

9} , Markus Barth ₁₀ , Marco Battiston ₁₁ , Christian Büchel ₁₂ , Matthew Budde ₁₃ , Virginie Callot _{14,

15} , Anna J E Combes ₁₆ , Benjamin De Leener _{17,

18} , Maxime Descoteaux _{19,

20} , Paulo Loureiro de Sousa ₂₁ , Marek Dostál ₂₂ , Julien Doyon ₂₃ , Adam Dvorak ₂₄ , Falk Eippert ₂₅ , Karla R Epperson ₂₆ , Kevin S Epperson ₂₆ , Patrick Freund ₂₇ , Jürgen Finsterbusch ₁₂ , Alexandru Foias ₁ , Michela Fratini _{28,

29} , Issei Fukunaga ₃₀ , Claudia A M Gandini Wheeler-Kingshott _{11,

31,

32} , Giancarlo Germani ₃₂ , Guillaume Gilbert ₃₃ , Federico Giove _{29,

34} , Charley Gros _{1,

5} , Francesco Grussu _{11,

35} , Akifumi Hagiwara ₃₀ , Pierre-Gilles Henry ₃₆ , Tomáš Horák ₃₇ , Masaaki Hori ₃₈ , James Joers ₃₆ , Kouhei Kamiya ₃₉ , Haleh Karbasforoushan _{40,

41} , Miloš Keřkovský ₂₂ , Ali Khatibi _{23,

42} , Joo-Won Kim ₄₃ , Nawal Kinany _{44,

45} , Hagen Kitzler ₄₆ , Shannon Kolind _{6,

24,

47} , Yazhuo Kong _{48,

49,

50} , Petr Kudlička ₃₇ , Paul Kuntke ₄₆ , Nyoman D Kurniawan ₅ , Slawomir Kusmia _{51,

52,

53} , René Labounek _{54,

55} , Maria Marcella Laganà ₅₆ , Cornelia Laule ₅₇ , Christine S Law ₅₈ , Christophe Lenglet ₃₆ , Tobias Leutritz ₅₉ , Yaou Liu _{60,

61} , Sara Llufriu ₆₂ , Sean Mackey ₅₈ , Eloy Martinez-Heras ₆₂ , Loan Mattera ₆₃ , Igor Nestrasil _{36,

54} , Kristin P O'Grady _{16,

64} , Nico Papinutto ₆₅ , Daniel Papp _{1,

50} , Deborah Pareto ₆₆ , Todd B Parrish ₄₀ , Anna Pichiecchio _{31,

32} , Ferran Prados _{11,

52,

67} , Àlex Rovira ₆₆ , Marc J Ruitenberg ₆₈ , Rebecca S Samson ₁₁ , Giovanni Savini ₃₂ , Maryam Seif _{27,

59} , Alan C Seifert ₄₃ , Alex K Smith ₅₀ , Seth A Smith _{16,

64} , Zachary A Smith ₆₉ , Elisabeth Solana ₆₂ , Yuichi Suzuki ₃₉ , George Tackley ₅₁ , Alexandra Tinnermann ₁₂ , Jan Valošek ₇₀ , Dimitri Van De Ville _{44,

45} , Marios C Yiannakas ₁₁ , Kenneth A Weber ₅₈ , Nikolaus Weiskopf _{59,

71} , Richard G Wise _{51,

72} , Patrik O Wyss ₄ , Junqian Xu ₄₃

Affiliation

NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.
Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Quebec, Canada.
Mila-Quebec AI Institute, Montreal, Quebec, Canada.
Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland.
Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.
Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, USA.
School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Queensland, Australia.
NMR Research Unit, Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Aix-Marseille Univ, CNRS, CRMBM, Marseille, France.
APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France.
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Computer and Software Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.
CHU Sainte-Justine Research Centre, Montreal, Quebec, Canada.
Centre de Recherche CHUS, CIMS, Sherbrooke, Quebec, Canada.
Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science department, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Université de Strasbourg, CNRS, ICube, Strasbourg, France.
UHB - University Hospital Brno and Masaryk University, Department of Radiology and Nuclear Medicine, Brno, Czech Republic.
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Richard M. Lucas Center, Stanford University School of Medicine, Stanford, CA, USA.
Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland.
Institute of Nanotechnology, CNR, Rome, Italy.
IRCCS Santa Lucia Foundation, Rome, Italy.
Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.
Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy.
MR Clinical Science, Philips Healthcare, Markham, Ontario, Canada.
CREF - Museo storico della fisica e Centro studi e ricerche Enrico Fermi, Rome, Italy.
Radiomics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Multimodal and functional imaging laboratory, Central European Institute of Technology (CEITEC), Brno, Czech Republic.
Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan.
Department of Radiology, the University of Tokyo, Tokyo, Japan.
Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, USA.
Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
BioMedical Engineering and Imaging Institute (BMEII), Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Institute of Bioengineering/Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Institute of Diagnostic and Interventional Neuroradiology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Department of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia, Canada.
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Wellcome Centre For Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
CUBRIC, Cardiff University, Wales, UK.
Centre for Medical Image Computing (CMIC), Medical Physics and Biomedical Engineering Department, University College London, London, UK.
Epilepsy Society MRI Unit, Chalfont St Peter, UK.
Division of Clinical Behavioral Neuroscience, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Departments of Neurology and Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic.
IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
Departments of Radiology, Pathology & Laboratory Medicine, Physics & Astronomy; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain.
Fondation Campus Biotech Genève, Geneva, Switzerland.
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Neuroradiology Section, Vall d'Hebron University Hospital, Barcelona, Spain.
E-health Centre, Universitat Oberta de Catalunya, Barcelona, Spain.
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany.
Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio University" of Chieti-Pescara, Chieti, Italy.

Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.

中文翻译：

脊髓定量 MRI 的通用采集协议

定量脊髓 (SC) 磁共振成像 (MRI) 提出了许多挑战，包括缺乏标准化的成像协议。在这里，我们为来自三个主要制造商：GE、飞利浦和西门子的 3T MRI 系统的用户提出了一个前瞻性统一的定量 MRI 协议，我们将其称为脊柱通用协议。该协议提供了评估 SC 宏观结构和微观结构完整性的指导：用于 SC 横截面积计算的 T1 加权和 T2 加权成像、灰质横截面积的多回波梯度回波以及用于评估的磁化转移和扩散加权成像白质微观结构。在同一作者的另一篇配套论文中，使用脊柱通用协议获取了 42 个中心 260 名健康受试者的数据。 Spine 通用协议的关键细节也可以在开放获取文档中找到，该文档可以在 https://github.com/spine-generic/protocols 中找到。该协议将作为研究人员和临床医生实施新的 SC 成像计划的起点，以便将来将 SC 纳入神经成像协议中将更加常见。该协议可以由任何经过培训的 MR 技术人员或熟悉 MRI 采集的研究人员/临床医生来实施。

更新日期：2021-08-16

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