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Hantzsch-like synthesis of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to arene or heteroarene cores utilizing bis(sulfanediyl)bis(6-aminopyrimidin-4-ones) as precursors
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-08-07 , DOI: 10.1007/s00706-021-02825-4
Hadeer M. Diab 1 , Mostafa E. Salem 1 , Ismail A. Abdelhamid 1 , Ahmed H. M. Elwahy 1
Affiliation  

A novel series of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) which are linked to benzene, pyridine, or thieno[4,5-d]thiophene cores were prepared to via multicomponent reaction of bis(sulfanediyl))bis(6-aminopyrimidin-4(1H)-ones) with two equivalents of both dimedone and the appropriate aromatic aldehyde. The target molecules were alternatively prepared via the bis-alkylation reactions of the appropriate 5-aryl-2-thioxohexahydropyrimido[4,5-b]quinoline-4,6-dione with the corresponding dibromo compounds.

Graphic abstract



中文翻译:

使用双(硫烷二基)双(6-氨基嘧啶-4-酮)作为前体连接到芳烃或杂芳烃核的双(硫烷二基)双(四氢嘧啶并[4,5-b]喹啉-4,6-二酮)的类似汉茨奇合成

通过多组分制备了一系列与苯、吡啶或噻吩并[4,5- d ]噻吩核相连的新型(硫烷二基(四氢嘧啶并[4,5 - b ]喹啉-4,6-二酮)的反应(硫))(6-氨基嘧啶-4(1 ħ) -酮)与两个双甲酮的两个当量和适当的芳族醛。或者通过合适的 5-芳基-2-硫代六氢嘧啶并[4,5 - b ]喹啉-4,6-二酮与相应的二溴化合物的烷基化反应制备目标分子。

图形摘要

更新日期:2021-08-09
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