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Hantzsch-like synthesis of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to arene or heteroarene cores utilizing bis(sulfanediyl)bis(6-aminopyrimidin-4-ones) as precursors

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Abstract

A novel series of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) which are linked to benzene, pyridine, or thieno[4,5-d]thiophene cores were prepared to via multicomponent reaction of bis(sulfanediyl))bis(6-aminopyrimidin-4(1H)-ones) with two equivalents of both dimedone and the appropriate aromatic aldehyde. The target molecules were alternatively prepared via the bis-alkylation reactions of the appropriate 5-aryl-2-thioxohexahydropyrimido[4,5-b]quinoline-4,6-dione with the corresponding dibromo compounds.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

    Hadeer M. Diab, Mostafa E. Salem, Ismail A. Abdelhamid & Ahmed H. M. Elwahy

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  1. Hadeer M. Diab
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  2. Mostafa E. Salem
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  3. Ismail A. Abdelhamid
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  4. Ahmed H. M. Elwahy
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Correspondence to Ismail A. Abdelhamid or Ahmed H. M. Elwahy.

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Diab, H.M., Salem, M.E., Abdelhamid, I.A. et al. Hantzsch-like synthesis of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to arene or heteroarene cores utilizing bis(sulfanediyl)bis(6-aminopyrimidin-4-ones) as precursors. Monatsh Chem 152, 967–976 (2021). https://doi.org/10.1007/s00706-021-02825-4

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