Xp11 translocation renal cell carcinoma (tRCC) characterized by the rearrangement of the TFE3 is recently identified as a unique subtype of RCC that urgently requires effective prevention and treatment strategies. Therefore, determining suitable therapeutic targets and fully understanding the biological significance of tRCC is essential. The importance of autophagy is increasingly acknowledged because it shows carcinogenic activity or suppressor effect. Autophagy is a physiological cellular process critical to maintaining cell homeostasis, which is involved in the lysosomal degradation of cytoplasmic organelles and macromolecules via the lysosomal pathway, suggesting that targeting autophagy is a potential therapeutic approach for cancer therapies. However, the underlying mechanism of autophagy in tRCC is still ambiguous. In this review, we summarize the autophagy-related signaling pathways associated with tRCC. Moreover, we examine the roles of autophagy and the immune response in tumorigenesis and investigate how these factors interact to facilitate or prevent tumorigenesis. Besides, we review the findings regarding the treatment of tRCC via induction or inhibition of autophagy. Hopefully, this study will shed some light on the functions and implications of autophagy and emphasize its role as a potential molecular target for therapeutic intervention in tRCC.

Xp11 易位肾细胞癌 (tRCC) 以TFE3重排为特征最近被确定为一种独特的 RCC 亚型，迫切需要有效的预防和治疗策略。因此，确定合适的治疗靶点并充分了解 tRCC 的生物学意义至关重要。自噬的重要性日益得到认可，因为它显示出致癌活性或抑制作用。自噬是一种对维持细胞稳态至关重要的生理细胞过程，它通过溶酶体途径参与细胞质细胞器和大分子的溶酶体降解，这表明靶向自噬是癌症治疗的潜在治疗方法。然而，tRCC中自噬的潜在机制仍然不明确。在这篇综述中，我们总结了与 tRCC 相关的自噬相关信号通路。而且，我们研究了自噬和免疫反应在肿瘤发生中的作用，并研究这些因素如何相互作用以促进或预防肿瘤发生。此外，我们回顾了通过诱导或抑制自噬治疗 tRCC 的研究结果。希望这项研究能够阐明自噬的功能和意义，并强调其作为治疗干预 tRCC 的潜在分子靶点的作用。