Abstract
Xp11 translocation renal cell carcinoma (tRCC) characterized by the rearrangement of the TFE3 is recently identified as a unique subtype of RCC that urgently requires effective prevention and treatment strategies. Therefore, determining suitable therapeutic targets and fully understanding the biological significance of tRCC is essential. The importance of autophagy is increasingly acknowledged because it shows carcinogenic activity or suppressor effect. Autophagy is a physiological cellular process critical to maintaining cell homeostasis, which is involved in the lysosomal degradation of cytoplasmic organelles and macromolecules via the lysosomal pathway, suggesting that targeting autophagy is a potential therapeutic approach for cancer therapies. However, the underlying mechanism of autophagy in tRCC is still ambiguous. In this review, we summarize the autophagy-related signaling pathways associated with tRCC. Moreover, we examine the roles of autophagy and the immune response in tumorigenesis and investigate how these factors interact to facilitate or prevent tumorigenesis. Besides, we review the findings regarding the treatment of tRCC via induction or inhibition of autophagy. Hopefully, this study will shed some light on the functions and implications of autophagy and emphasize its role as a potential molecular target for therapeutic intervention in tRCC.
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Abbreviations
- MiT:
-
Microphthalmia transcription factor
- RCC:
-
Renal cell carcinoma
- tRCC:
-
Translocation RCC
- ccRCC:
-
Clear cell renal cell carcinomas
- pRCC:
-
Papillary renal cell carcinomas;
- MiT:
-
Microphthalmia transcription factor\
- CMA:
-
Chaperon-mediated autophagy
- AMPK:
-
AMP active protein kinase
- LPS:
-
Lipopolysaccharide
- HCQ:
-
Hydroxychloroquine
- CQ:
-
Chloroquine
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This present study was supported in part by the National Natural Science Foundation of China (grant numbers: 81660755), and the Science and Technology Project of Shenzhen of China (Grant Numbers: JCYJ20170307160524377 and JCYJ20190808162605484).
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Sun, H., Wei, X. & Zeng, C. Autophagy in Xp11 translocation renal cell carcinoma: from bench to bedside. Mol Cell Biochem 476, 4231–4244 (2021). https://doi.org/10.1007/s11010-021-04235-w
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DOI: https://doi.org/10.1007/s11010-021-04235-w