Selective Removal of Florfenicol from Fetal Bovine Serum by Restricted Access Media–Magnetic Molecularly Imprinted Polymers,Chromatographia

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Selective Removal of Florfenicol from Fetal Bovine Serum by Restricted Access Media–Magnetic Molecularly Imprinted Polymers
Chromatographia ( IF 1.2 ) Pub Date : 2021-08-03 , DOI: 10.1007/s10337-021-04074-3
Siyu Guo ₁ , Shanshan Wu ₁ , Shanwen Zhao ₁ , Xiaoxiao Wang ₁ , Tianpei Cai ₁ , Jianmin li ₁ , Bolin Gong ₁

Affiliation

Unique restricted access media-magnetic molecularly imprinted polymers (RAM–MMIPs) were prepared as magnetic solid-phase extraction (MSPE) material for florfenicol (FF) and are combined with HPLC–UV to extract FF from fetal bovine serum samples. Under the optimization conditions, the resulting materials had a uniform imprinted layer, acceptable adsorption amounts (22.92 mg/g), rapid binding kinetics (80 min) and satisfactory selectivity. In addition, RAM–MMIPs presented satisfactory recoveries (95.6–102.1%), relative standard deviation (RSD) (2.7–3.9%) and lower limits of detection (LOD) (10.5 μg/L). The method was applied to the real samples. Compared with other reported methods, this method exhibits the advantages of simple, fast and, efficient operation, using a relatively small amount of the RAM–MMIPs adsorbent. The developed method can enrich FF from fetal bovine serum samples.

Graphic abstract

中文翻译：

限制接触介质-磁性分子印迹聚合物选择性去除胎牛血清中的氟苯尼考

制备了独特的限制访问介质-磁性分子印迹聚合物（RAM-MMIPs）作为氟苯尼考（FF）的磁性固相萃取（MSPE）材料，并与 HPLC-UV 结合从胎牛血清样品中提取 FF。在优化条件下，所得材料具有均匀的印迹层、可接受的吸附量（22.92 mg/g）、快速的结合动力学（80 min）和令人满意的选择性。此外，RAM-MMIP 具有令人满意的回收率 (95.6–102.1%)、相对标准偏差 (RSD) (2.7–3.9%) 和检测下限 (LOD) (10.5 μg/L)。该方法应用于实际样品。与其他报道的方法相比，该方法使用相对少量的 RAM-MMIPs 吸附剂，具有操作简单、快速、高效的优点。

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更新日期：2021-08-03

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