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Mitochondrial UPR through generations
Nature Cell Biology ( IF 17.3 ) Pub Date : 2021-08-02 , DOI: 10.1038/s41556-021-00729-3
Mooncheol Park 1 , Meng C Wang 1, 2, 3
Affiliation  

Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria perturbation.

中文翻译:

几代人的线粒体UPR

神经元线粒体扰动会在外周组织细胞中非自主地引发线粒体未折叠蛋白反应 (UPRmt),这取决于 Wnt 信号通路。现在的一项研究表明,Wnt 介导的母系遗传线粒体 DNA 的增加是神经元线粒体扰动诱导的跨代 UPRmt 的原因。
更新日期:2021-08-02
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